一、个人简介
杨子毅，男，1984年02月出生，博士、副研究员、硕士生导师。参与或负责新药申报、药物制剂技术的产业化：负责开发氯雷伪麻缓释微丸的处方设计及产业化研究；负责开发3类新药阿奇霉素滴眼液，品种已获得临床批件。主持多项企业仿制药及创新制剂研发工作，包括麦考酚钠肠溶片、泊沙康唑肠溶片、盐酸文拉法辛缓释微丸等。
学习经历：
2009.10～2013.07 英国University of East Anglia，博士
2007.09～2009.09 沈阳药科大学药剂学专业，硕士
2003.09～2007.07 沈阳药科大学药剂学专业，学士
工作经历：
2014.12 澳门威斯人(中国)集团有限公司官网
2013.8～2014.9英国University College London 药公司，博士后
二、研究领域
药剂学；仿制药一致性评价；创新制剂的研究与设计；口服缓控释、速释制剂；长效注射剂；外用制剂。
三、荣誉奖励
指导员工参加“挑战杯”全国老员工课外学术科技作品比赛，获得国家三等奖和江苏省一等奖。
四、学术成果
（一）代表性项目
[1]2015江苏省“双创人才”
[2]2016国家自然科学基金青年基金
[3]麦考酚钠肠溶片研发，企业合作项目，无锡福祈制药有限公司，主持
[4]盐酸文拉法辛缓释胶囊、达比加群酯胶囊一致性评价，企业合作项目，北京万生药业有限公司，主持
[5]钙片工艺耐用性提升及粉末直压法技术开发，企业合作项目，无限极（中国）有限公司，主持
[6]紫草婴儿软膏研究开发，企业合作项目，云南希陶绿色药业有限公司，主持
[7]泊沙康唑肠溶片研发，企业合作项目，无锡福祈制药有限公司，主持
[8]凯爱瑞（Kerry）配料贸易有限公司技术咨询顾问
（二）代表性论文
[1]Z. Yang, L.Liu, L.L.Su,X.Q. Wu,Y.C.Wang,L.Liu,X. Lin*.Design of a Zero-order Sustained Release PLGA Microspheres for Palonosetron Hydrochloride with High Encapsulation Efficiency.International Journal of Pharmaceutics, 2020.
[2]Z. Yang, Hu Y, Tang G, Dong MM, Liu Q, X. Lin*.Development of ibuprofen dry suspensions by hot melt extrusion: Characterization, physical stability and pharmacokinetic studies.Journal of Drug Delivery Science and Technology. 2019.
[3]Z. Yang and D.Q.M. Craig. Monitoring film coalescence from aqueous polymeric dispersions using atomic force microscopy: Surface topographic and nano-adhesion studies. Asian Journal of Pharmaceutical Sciences(2018).
[4]X. Lin, H. Yang, L. Su, Z. Yang, and X. Tang. Effect of size on the in vitro/in vivo drug release and degradation of exenatide-loaded PLGA microspheres. Journal of Drug Delivery Science and Technology. 45:346-356 (2018).
[5]X. Lin, L. Su, N. Li, Y. Hu, G. Tang, L. Liu, H. Li, and Z. Yang. Understanding the mechanism of dissolution enhancement for poorly water-soluble drugs by solid dispersions containing Eudragit® E PO. Journal of Drug Delivery Science and Technology. 48:328-337 (2018).
[6]X. Lin, Y. Hu, L. Liu, L. Su, N. Li, J. Yu, B. Tang, and Z. Yang. Physical Stability of Amorphous Solid Dispersions: a Physicochemical Perspective with Thermodynamic, Kinetic and Environmental Aspects. Pharmaceutical Research. 35:125 (2018).
[7]X. Lin, J. Wang, Y. Xu, X. Tang, J. Chen, Y. Zhang, Y. Zhang, and Z. Yang. Tracking the effect of microspheres size on the drug release from a microsphere/sucrose acetate isobutyrate (SAIB) hybrid depot in vitro and in vivo. Drug Development and Industrial Pharmacy. 42:1455-1465 (2016).
[8]Z. Yang, K. Nollenberger, J. Albers, D. Craig, and S. Qi. Molecular Indicators of Surface and Bulk Instability of Hot Melt Extruded Amorphous Solid Dispersions. Pharmaceutical Research. 32:1210-1228 (2015).
[9]X. Lin, Y. Xu, X. Tang, Y. Zhang, J. Chen, Y. Zhang, H. He, and Z. Yang. A Uniform Ultra-Small Microsphere/SAIB Hybrid Depot with Low Burst Release for Long-Term Continuous Drug Release. Pharmaceutical Research. 32:3708-3721 (2015).
[10]Z. Yang, K. Nollenberger, J. Albers, and S. Qi. Molecular Implications of Drug–Polymer Solubility in Understanding the Destabilization of Solid Dispersions by Milling. Molecular Pharmaceutics. 11:2453-2465 (2014).
[11]Z. Yang, K. Nollenberger, J. Albers, J. Moffat, D. Craig, and S. Qi. The effect of processing on the surface physical stability of amorphous solid dispersions. European Journal of Pharmaceutics and Biopharmaceutics. 88:897-908 (2014).
[12]Z. Yang, K. Nollenberger, J. Albers, D. Craig, and S. Qi. Microstructure of an Immiscible Polymer Blend and Its Stabilization Effect on Amorphous Solid Dispersions. Molecular Pharmaceutics. 10:2767-2780 (2013).
五、联系方式
通讯地址：江苏省无锡市蠡湖大道1800号澳门威斯人(中国)集团有限公司官网
邮编：214122
邮箱：ziggyyang@163.com
【以上资料更新日期】2020年04月
