一、个人简介

苏畅，女，1991年04月出生，博士、助理研究员。

主要经历：

2010.09 — 2014.06集团药公司工学学士

2014.09 — 2017.06集团药公司工学硕士

2017.09 — 2021.06集团药公司工学博士

2021.10 —至今 集团药公司博士后

二、研究领域

(1)角蛋白生物材料的制备与活性评价；

(2)角蛋白在组织工程材料中的应用；

(3)角蛋白生物质资源的绿色处理与高值化利用；

(4)角蛋白酶的蛋白质工程改造与生物信息学辅助设计；

(5)角蛋白酶基因的挖掘、克隆与异源表达。

三、学术成果

（一）代表性论文

[1]Su C, Gong J S, Qin A Q, Li H, Li H, Qin J F, Qian J Y, Xu Z H, Shi J S. A combination of bioinformatics analysis and rational design strategies to enhance keratinase thermostability for efficient biodegradation of feathers[J].Science of the Total Environment, 2022, 151824.

[2]Su C, Gong J S, Qin J F, Li H, Li H, Xu Z H, Shi J S. The tale of a versatile enzyme: Molecular insights into keratinase for its industrial dissemination[J].Biotechnology Advances, 2020, 45(3):107655.

[3]Su C, Gong J S, Sun Y X, Qin J F, Zhai S, Li H, Li H, Lu Z M, Xu Z H, Shi J S. Combining

Pro-peptide Engineering and Multisite Saturation Mutagenesis to Improve the Catalytic Potential of Keratinase[J].ACS Synthetic Biology, 2019, 8 (2): 425-433.

[4]Su C, Gong J S, Qin J F, He J M, Zhou Z C, Jiang M, Xu Z H, Shi J S. Glutathione enables full utilization of wool wastes for keratin production and wastewater decolorization[J].Journal of Cleaner Production, 2020, 270: 122092.

[5]Su C, Gong J S, Ye J P, He J M, Li R Y, Jiang M, Geng Y, Zhang Y, Chen J H, Xu Z H, Shi J S. Enzymatic Extraction of Bioactive and Self-Assembling Wool Keratin for Biomedical Applications[J]. Macromolecular Bioscience, 2020, 20 (9): e2000073. (Front Cover封面)

[6]Su, C, Gong, J S, Zhang, R X, Tao, L Y, Xu Z H, Shi, J S. A novel alkaline surfactant-stable keratinase with superior feather-degrading potential based on library screening strategy.International journal of biological macromolecules, 2017, 95, 404-411.

[7] Ye J P, Gong J S,Su C, Liu Y G, Jiang M, Pan H P, Li R Y, Geng Y, Xu Z H, Shi, J S. Fabrication and characterization of high molecular keratin based nanofibrous membranes for wound healing[J].Colloids and Surfaces B: Biointerfaces, 2020, 194.

[8] Zhang R X, Gong J S,Su C, Qin J F, Li H, Li H, Shi J S, Xu Z H. Recombinant expression and molecular engineering of the keratinase fromBrevibacillus parabrevisfor dehairing performance[J].Journal of Biotechnology, 2020, 320: 57-65.

[9] Tao L Y, Gong J S,Su C, Jiang M, Li H, Li H, Lu Z M, Xu Z H, Shi J S. Mining and Expression of a Metagenome-Derived Keratinase Responsible for Biosynthesis of Silver Nanoparticles[J].ACS Bio-materials Science and Engineering, 2018, 4: 1307-1315.

（二）主要授权专利

[1] Shi J S; Xu Z H; Gong J S; Li H;Su C. An improved industrial keratinase via genetic engineering and use thereof [P],美国专利, 2018.4.9,US16/343,630

[2] 龚劲松，陶丽妍，苏畅，许正宏，史劲松. 一种经热稳定性改造的角蛋白酶突变体[P]，中国专利，CN2018109332265

四、联系方式

通讯地址：江苏省无锡市蠡湖大道1800号澳门威斯人(中国)集团有限公司官网

邮编：214122

邮箱：Emilysu1991@126.com

【以上资料更新日期】：2022年2月